Minimally. Some people like to disable on board peripherals to reduce interrupts and oversight load.
Since you are likely to be using at least one SATA port you probably will not be doing this.
If it is mounted and you are running Windows 10, it is likely to be pounded as is the fate of such disks.
Scans and indexing. If the disk is slow then CPU consumption will be lower as the fire is not being fed as fast. But still more cumulative work.
I know you are not asking, but use it for media files or Steam games that don't need the speed. Things that can be re-downloaded when it does eventually fail.
Or put it in an enclosure and mount it on demand.